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CamSol Intrinsic   Sequence-based method of predicting protein solubility and generic aggregation propensity.
CamSol Intrinsic pH-dependent   Sequence-based method of predicting protein solubility and generic aggregation propensity as a function of pH.
CamSol-PTM   Sequence-based method of predicting the solubility of peptides and proteins containing post-translationally modified and/or non natural amino acids.
CamSol Structurally Corrected   Structure-based method of calculating a solubility profile, which accounts for the proximity of the amino acids in the structure and for their solvent exposure. The structurally corrected profile can be color-coded on the structure of the protein to spot patches of low solubility that may elicit self-assembly.
CamSol Combination automated design  

A method for the automated structure-based optimisation of solubility and conformational stability of antibodies and proteins. (Otherwise go to the legacy version of CamSol design from the 2015 paper)

δ2D   A method of calculating secondary structure populations of proteins from their chemical shifts.
s2D   A method of predicting secondary structure populations of proteins from the amino acid sequence.
AbNatiV   A deep-learning tool for assessing the nativeness of antibodies and nanobodies.
Camcoil   A method of calculating random coil chemical shifts from protein sequences.
Parapred   A method of predicting from antibody sequences the residues in contact with the antigen (the paratope).
PDBcleaner   Cleans a PDB file so that it can be used as input for computational calculations.



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This web-server and its associated data and services are for research purpose only, not for clinical or commercial use. It is a free, non-profit service to the scientific community. The responsibility of researchers at the Chemistry of Health is limited to applying best efforts in providing and publishing good programs and data. The University of Cambridge has no responsibility for the use of results, data, or information, which have been provided through this web-server.

While we try to keep the sequences/data users upload to this web server as secure as possible, we are not cyber-security experts. Do not use this web server to process proprietary or sensitive data. Most algorithms can be freely downloaded and run locally, and a licence for the CamSol method can be purchased from Cambridge Enterprise.